M98 Resveratrol Complete (M98-RC) - Better Than Super Micronized - Bulk Powder - 25 Grams Per Container - 450 mg Trans-Resveratrol Soluble Type Per Serving. Actual product images may vary due to product enhancement or label changes. Our 30-day guarantee does not cover this powder product. There are no refunds on this product.
The M98 Resveratrol Complete (M98-RC) is estimated to be absorbed virtually completely (98.4% metabolized) compared to regular resveratrol1,2. While dry M98 super micronized resveratrol increases absorption when used with different emulsifiers (between 3x to 10x depending on the emulsifier used), the M98 micronized resveratrol is still mainly passively absorbed by a single cellular transport system and is limited.
RevGenetics has decided to help provide complete active and passive absorption, using a type of trans-Resveratrol that is absorbed passively with a much higher solubility and actively through glucose transports. This is why we say Complete Absorption Resveratrol™ on the jar. It helps provide both complete active and passive absorption methods.
In short: The M98 Resveratrol Complete is absorbed using both active and passive cellular transport systems, is 25x more soluble*, and has a much longer half-life (approx. 4 hours)1 than standard resveratrol. This means that M98 Resveratrol Complete not only is absorbed phenomenally well but lasts much much longer than standard resveratrol (approx. 8-14 minutes)3, activating the Sirtuin longevity genes in the process.
Is this M98 Resveratrol Complete (M98-RC) completely water-soluble? No, the M98 Resveratrol Complete is not fully water-soluble, but it is much more soluble than standard resveratrol. When mixing into drinks, you will still see particles in the drink or shake. However, this doesn't matter as the M98 Resveratrol Complete is absorbed through passive diffusion and active transport via sodium-dependent glucose transporter (SGLT1), mainly existing in the stomach and intestines3.
Will M98 Resveratrol Complete (M98-RC) be completely absorbed? After reviewing the research in published journals, we believe it supports our belief that up to 98% can be absorbed, according to studies as Transepithelial transport of M98-RC clearly occurs with the favorable apparent permeability coefficient (Papp) about 10 x 10-6 cm/s for the apical to basolateral flux, suggesting virtually complete absorption of M98-RC in humans, with its combination of the active absorption along with regular passive absorption5.
1 Pharm Biol, 2013; 51(11): 1347–1354
2 J Agric Food Chem 57:4572
3 Nat Rev Drug Discov, 2006, Jun; 5(6):493-506
4 J Agric Food Chem 53:798–803.
5 Pharm Res 14:763-766